The mitochondrial Ca uniporter: regulation by auxiliary subunits and signal transduction pathways
نویسندگان
چکیده
Bong Sook Jhun,* Jyotsna Mishra,* Sarah Monaco, Deming Fu, Wenmin Jiang, Shey-Shing Sheu, and Jin O-Uchi Cardiovascular Research Center, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island; and Center for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania
منابع مشابه
The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways.
Mitochondrial Ca(2+) homeostasis, the Ca(2+) influx-efflux balance, is responsible for the control of numerous cellular functions, including energy metabolism, generation of reactive oxygen species, spatiotemporal dynamics of Ca(2+) signaling, and cell growth and death. Recent discovery of the molecular identity of the mitochondrial Ca(2+) uniporter (MCU) provides new possibilities for applicat...
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